EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

COMPARISON OF CLINICAL AND MICROBIOLOGIC EFFICACY OF 0.12% CHX SOLUTION AGAINST 1% CHX GLUCONATE GEL APPLIED USING TRAYS FOR RELIEVING GINGIVITIS AND INHIBITION OF DENTAL PLAQUE FORMATION: A PILOT STUDY

*Dr. Dhanashree More Patil, Dr. Mona U. Shah, Dr. Vidhi Kevadia, Dr. Vishnu Maske

ABSTRACT

Chlorhexidine is an effective antibacterial agent and is used in dental treatment in several formulations. The aim of
the study is to compare the clinical and microbiological efficacy of 1%CHX gel applied using trays with 0.12%
CHX gluconate mouthwash in patients with chronic gingivitis. 30 participants are randomly divided into two
groups: test group (1% CHX gel) and control group (0.12% Chlorhexidine mouthwash). Participants were provided
with CHX products and were instructed to use each product for 2 week. Clinical and microbiological evaluation
was done by recording gingival index (GI), plaque index (PI) and anaerobic colony forming units (CFU). The
results were analyzed using independent t test (p<0.001). The GI and PI were decreased more in the test group
compared to the control group 2 weeks later. In both the groups, anaerobic colony forming units (CFU) also
decreased (p< 0.001) after 2 weeks, the CFU score decreased relatively more in CHX gel group than CHX solution
group. These results suggest that 1% CHX gel is more effective in reducing gingivitis than 0.12% CHX solution.
Therefore, 1% CHX gel can be preferred to be used in gingivitis and for non-surgical treatment of periodontal
disease patients.

Keywords: Participants were provided with CHX products and were instructed to use each product for 2 week.


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