FORMULATION AND EVALUATION OF IBUPROFEN CUBOSOMAL TRANSDERMAL PATCH

Sreekavya B.*, Disha andf Santhosh M. Mathews

ABSTRACT

Cubosome loaded transdermal patch formulation may enhance the release rate of drug for quick onset of action.
With this view the present study was aimed to formulate and evaluate the ibuprofen cubosome loaded transdermal
patches. In our previous effort, nine ibuprofen loaded cubosome formulations were prepared and evaluated
successfully. Based on the results of evaluation, three cubosome formulations namely C3, C6 and C9 were selected
for the preparation of transdermal patches namely TP1, TP2 and TP3 respectively. The transdermal patches were
formulated by solvent casting method. The prepared patches were evaluated to ensure their quality. The physical
appearance evaluation revealed that all the patches were white in colour, had the appearance of a smooth,
translucent flat surface with good flexibility. Results of average weight, thickness uniformity, drug content, folding
endurance and percentage moisture absorption assessment ascertained the quality of prepared transdermal patches.
The in vitro drug release evaluation and drug release kinetics study indicated that the formulation TP3 was best fit
towards zero order and Higuchi models followed by TP1 formulation and TP2 formulation showed significant
results in terms of both zero order and Higuchi models evaluation. The formulation TP3 was selected for the
stability study based on the scores of release kinetics study which indicated that there was no significant changes in
the physical characteristics and drug content of the tested transdermal patch TP3. Summarily, all the cubosome
loaded transdermal patches (TP1, TP2 and TP3) prepared in this study revealed a significant results in all the
evaluation procedures employed. Further research in these cubosome loaded transdermal patches in the direction of
in vivo evaluations may give more crucial data valuable for successful development of a novel sustained release
drug delivery system in the future.

Keywords: Ibuprofen, Cubosome, Transdermal patch, Formulation, Characterization.