A STUDY TO EVALUATE THE EFFECT OF GATIFLOXACIN ON BLOOD SUGAR LEVELS IN DIABETIC AND NON DIABETIC RABBITS – A CHRONIC PROSPECTIVE STUDY

Akash Khobragade*, Mrityunjay Khopkar, Sadiq Patel, Snehal Kosale and Kiran Paripelli

ABSTRACT

Introduction: The aim of the study is to evaluate the effects of gatifloxacin alone and in combination with glyburide on blood sugar levels in non-diabetic and alloxan induced rabbits. Methods: 24 hrs fasting animal‘s blood was collected for baseline investigations. After blood collection, alloxan was induced intravenously in 32 out of 40 rabbits. On day 2 FBS was repeated and other investigations were repeated on day 3. FBS and S. Insulin were repeated on day 7 of treatment. On day 14 of treatment (end day of treatment) the above mentioned investigations were repeated again. Results: After alloxan induction, FBS levels of gr-I, gr-II, gr-III, gr-IV at baseline were 93.63, 94.13, 93.88, 93.13 mg/dl, 24 hours after alloxan induction were 220.63, 220.86, 220.87, 220.88 mg/dl, 48 hours after alloxan induction were 221.13, 221, 222, 221 mg/dl. S.Insulin levels for the groups for baseline were 3.84, 3.78, 3.74, 3.79 mg/dl; 48 hours after alloxan were 1.80, 1.81, 1.80, 1.83 mg/dl. FBS levels after 2 weeks of Gatifloxacin medication in gr-III and gr V for baseline were 222, 93.63 mg/dl, at 1week were 220.75, 93.25mg/dl, at 2 weeks were 220.38, 93.38 mg/dl. S. Insulin levels for both above groups and after 2 weeks of gatifloxacin medication for baseline were 1.80, 3.76 mg/dl, at 1 week 1.82, 3.77mg/dl, at 2 weeks 1.84, 3.78 mg/dl. Conclusion: Gatifloxacin, at therapeutic doses, had no effect on blood glucose levels or insulin levels, even on prolonged intake, both in diabetics and non-diabetics. Concurrent administration of gatifloxacin and glyburide did not significantly reduce blood glucose concentrations, than when glyburide is administered alone, in diabetics. Gatifloxacin should be avoided as an outpatient or as an over the counter drug. It may, be used on an inpatient basis as the recipient is under medical observation.

Keywords: Diabetes Mellitus, Alloxan, Gatifloxacin, Glyburide, FBS, Insulin.