FORMULATION, DEVELOPMENT AND IN VITRO EVALUATION OF IN SITU NASAL GEL OF RIZATRIPTAN BENZOATE

Minakshi R. Khairnar*, Sanjay B. Patil, Amol P. Thakare, Roshan R. Ghatmale, Gaurav N. Kasar, Lokesh Pawar and Dhashri S. Pawar

ABSTRACT

Rizatriptan benzoate, a potent triptan used for the acute treatment of migraine, faces challenges in achieving optimal bioavailability due to its low oral absorption and first-pass metabolism. The development of an in situ nasal gel could offer a viable alternative for rapid drug delivery, bypassing gastrointestinal degradation and first-pass metabolism. This study focuses on the formulation, development, and in vitro evaluation of an in situ nasal gel containing Rizatriptan benzoate. The gel was formulated using various gelling agents and evaluated for its physicochemical properties, gelation behavior, drug release, and nasal mucosal compatibility.

Keywords: Rizatriptan benzoate, In situ nasal gel, Formulation, Drug delivery, Nasal mucosa, Gelation.