INNOVATIVE DRUG DELIVERY SYSTEMS: EXPLORING ETHOSOMES AND TRANSETHOSOMES

Sugriv Ramesh Ghodake*, Vikas Damu Kunde and Vaibhavkumar Arun Jagtap

ABSTRACT

Ethosomes and transethosomes are advanced lipid-based vesicles designed to enhance drug delivery through the skin. This review explores their types, preparation methods, advantages, and challenges. Ethosomes use ethanol to increase skin permeability, while transethosomes incorporate additional penetration enhancers for improved transdermal delivery. Key preparation techniques include lipid film hydration and solvent injection. Advantages of these systems include controlled drug release, reduced systemic toxicity, and enhanced therapeutic efficacy, though they face issues like stability and environmental sensitivity. Characterization involves TEM, SEM, DLS, and drug entrapment efficiency assessments. Applications range from dermatology and cosmeceuticals to systemic drug delivery. Pharmacological evaluations highlight their effectiveness in anti-inflammatory, analgesic, and anti-gout treatments. Overall, ethosomes and transethosomes represent promising platforms for innovative drug delivery solutions.

Keywords: Ethosomes, Transethosomes, Drug Delivery, Skin Permeation Cosmeceuticals, Characterization Techniques, Transdermal Systems.