SYNTHESIS, ANTI MICROBIAL ACTIVITY AND DOCKING STUDY OF SALICYLANIDES

*A. P. Rajput and Sonali A. Patil

ABSTRACT

Discovery of new efficient antibiotics is very challenging task. Due to increasing resistance power of bacteria, fungi and viruses against many antibiotics; searching of effective antibiotic is more difficult job. Salicylanides were synthesized and evaluated for their antimicrobial activity in vitro. All the compounds are characterized by spectroscopic techniques such as FTIR, H1 NMR, C13 NMR and Mass. Molecular docking of these compounds is carried out in silico. Molecular docking of these compounds is done with β-Ketoacyl-acyl carrier protein synthase III from Escherichia coli (ecKAS III pdb id: 1HNJ) as a receptor responsible for growth of bacteria. The results show that all Salicylanides are excellent inhibitors of β-Ketoacyl-acyl carrier protein synthase III.

Keywords: Salicylanides, Molecular docking, antimicrobial activity, protein etc.