EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

ANTIBIOTIC CHARACTERIZATION AND STUDY OF THE SENSITIVITY OF SOME BACTERIAL STRAINS OF URINARY ORIGIN TO FLUEGGEA VIROSA (ROXB, EX WILLD.) ROYLE LEAF EXTRACTS

Soro Tinnèlo*, Kamagate Tidiane, Toure Abdoulaye, Kablan Ahmont Landry Claude and Coulibaly Adama

ABSTRACT

The increasing resistance of bacteria to antibiotics in the fight against urinary infections in recent decades constitutes a major public health concern. The objective of this study is to evaluate the antibacterial activity of Flueggea virosa leaves on multi-resistant urinary strains (Escherichia coli, Klebsiella spp, Proteus mirabilis and Staphylococcus spp). First of all, antibiotic profile of the bacterial strains was established according to the recommendations of the antibiogram committee of the French Society of Microbiology (CA-SFM). Then, antibacterial activity of aqueous and 70% hydro-ethanolic extracts of leaves of the plant was determined by punch well method in agar and dilution in liquid medium. The antibiotic profile revealed that all strains studied were multi-resistant with a minimum of 5 antibiotics. On the other hand, all the strains were very sensitive to F. vorosa extracts with diameters of the inhibition zones varying from 11.00 ± 1 mm to 22.00 ± 1 mm for the aqueous extract and 10. 66 ± 1.52 mm to 23.00 ± 0 mm for the hydro-ethanolic extract. Furthermore, the two extracts were active on all strains with MICs between 3.125 mg/ml and 12.5 mg/mL and MBCs oscillating between 3.125 mg/mL and 25 mg/mL. The MBC/MIC report indicates that both extracts had bactericidal power. These data would therefore justify the traditional use of this plant in the treatment of urinary and gynecological conditions in the North of Côte d’Ivoire.

Keywords: Flueggea virosa; Multi-resistance urinary strains; Antibacterial activity; bactericidal.


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