“A COMPREHENSIVE REVIEW: EXPLORING THE POTENTIAL OF NANOSUSPENSION-LOADED ORAL DISSOLVING FILMS: A MODERN APPROACH TO SOLUBILITY ENHANCEMENT

Bhargav M.* and Nimisha Jain

ABSTRACT

Conventional dosage forms are preferred for their ability to provide immediate drug release and rapid therapeutic
response. However, poor solubility is a common problem in drug development, often leading to inadequate
bioavailability. Enhancing drug solubility and oral bioavailability is a significant challenge in formulation
processes. Various approaches, such as pH adjustment, particle size reduction, Sono-crystallization, inclusion
complexation, liquid-solid methods, solid dispersion methods, self-emulsifying methods, supercritical fluid
processes, freeze drying, spray drying, and hot melt extrusion, are available to improve solubility and dissolution
rates. Choosing the right technique is crucial to enhance drug dissolution and bioavailability, preventing the
rejection of new chemical entities due to low solubility. Recently, nanosuspensions have garnered interest as a
promising method to enhance the bioavailability of poorly soluble drugs. These submicron colloidal particles,
ranging from 1 to 100 nm, offer unique advantages over traditional solubility enhancement methods. Techniques
like media milling and high-pressure homogenization have enabled the commercial production of stable
nanosuspensions. Nanosuspensions improve drug solubility in aqueous media, speeding up drug release and
achieving faster maximum plasma levels. They address issues of poor solubility and bioavailability, altering the
pharmacokinetics of drugs to improve safety and efficacy. Nanotechnology surpasses the limitations of
conventional solubility and bioavailability enhancement methods. Oral disintegrating films or strips use watersoluble
polymers to quickly hydrate with saliva, adhere to mucosal surfaces, and disintegrate within seconds,
releasing medication for Oro mucosal absorption when placed on the tongue or in the oral cavity. The mucosa, with
its thin membrane and large veins, is highly permeable, providing rapid drug bioavailability due to swift blood
flow. Oral films offer significant advantages over other dosage forms, including rapid dissolution and
disintegration in the oral cavity, reduced dosing intervals, and improved onset of action, efficacy, and safety
profiles.

Keywords: Nanosuspension, Solvent Casting Method, Oral Fast Dissolving Films, Enhanced Bioavailability, Water Insoluble Drugs, Nanotechnology.