FORMULATION AND EVALUATION OF FLOATING BILAYER TABLETS OF FUROSEMIDE

D. Amitha* and A. Gopi Reddy

ABSTRACT

The present work was carried out to design the floating drug delivery system to minimize the side effects, improve the prolongation of action, to reduce the frequency of administration. The objective of the present investigation was to develop a bi-layer floating tablets and to evaluate furosemide using direct compression technology. Xanthium gum, sodium bicarbonate, pvpk30 and some other ingredients are used and formed floating layer. The sustained layer contained furosemide and various ratios of polymers such as HPMC-K100M, HPMC-K4M. The floating behavior and in vitro dissolution studies were carried out in a USP XXIV type 2(paddle) apparatus in a stimulated gastric fluid. Final formulation released approximately 105% drug in 12 h in vitro, while the floating lag time was 105 sec and the tablet remained floatable throughout all the studies. Statistically significant differences were found among the drug release profile from different formulations. Final formulation that showed no change in appearance and the results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer level and physico-chemical properties of the drug.

Keywords: floating drug delivery, furosemide, bilayer tablets, HPMC-K100M, HPMC-K4M.