ROLE OF OMEGA-3 FATTY ACIDS IN SEVERE SEPSIS CASES

*Dr. Sameer Goyal M.B.B.S., M.D., Dr. Smita Barya M.B.B.S, M.S, Dr. Prakash Chandra Audichya M.B.B.S, M.D

ABSTRACT

Dietary supplements of omega-3 fatty acids have long been used to influence chronic inflammatory disorders. Omega – 3 fatty acids, derived primarily from fish oils, compete with other fatty acids for incorporation into cell membranes. This study was carried out in 70 patients suffering from severe sepsis admitted in ICU of Pacific Medical College and Hospital, Udaipur to evaluate the impact of omega-3 fatty acids on outcome variables in critically ill severe septic cases. The patients were randomly assigned into two treatment groups: Group I receiving Soya bean based Parenteral nutrition (SO group) and the group II was supplemented Fish oil with the Soy bean based Parenteral Nutrition (FO +SO group) for a period of seven days. The primary endpoints like Gas exchange (Pa02/Fio2), biochemical markers had a significant improvement over the course of nutritional therapy in the FO +SO group as compared to SO group. The duration of stay on Ventilator, no. of days in the ICU and Hospital also reduced significantly in Group II as compared to Group I.

Keywords: Parenteral nutrition, Omega 3 fatty acid, Severe sepsis, ARDS.