FORMULATION AND EVALUTION OF TOPICAL ANTIFUNGAL GEL CONTAINING FLUCONAZOLE

Gauri Ashok Phadtare*, Mukesh Tatyarao Mohite and Madhvi Anil Kuchekar

ABSTRACT

The present research has been undertaken with the aim to develop a topical gel formulation of Fluconazole. Fluconazole is an imidazole derivative and used for the treatment of local and systemic fungal infection. The oral use of Fluconazole is not much recommended as it has many side effects. Commercially Fluconazole topical gel preparation are not available in the market, thus this formulation is made for better patient compliance and to reduce the dose of drug and to avoid the side effects like liver damage and kidney damage. The gel was formulated by changing the polymer ratio. Formulation were evaluated for % yield, spredability, extrudability, washability and viscosity in-vitro drug release study, skin irritation study, stability testing and finally it was concluded that formulation F3 was the best formulation among these formulation.

Keywords: Fluconazole, Carbopol 934p, HPMC.