A STUDY ON SEVERITY OF DRUG INTERACTIONS AND THEIR INCLUSION IN VARIOUS DRUG INFORMATION COMPENDIA

*Gavini Siva Bharat, Maddineni Nagarjuna, Uppara Veerendra, Dr. Mohanraj Rathinavelu Mudhaliar, Narayana Goruntla

ABSTRACT

Medication incidents are a significant problem for all health systems in the world. Drug interactions are one cause of medication incidents. Drug interaction compendia can be used to populate clinical decision support systems. There has not been any comprehensive assessment of the validity of the severity classification used in the international drug interaction compendia. The current prospective observational study of six months duration was designed to assess the severity of drug interactions between various drug information compendia screened from prescriptions of general medicine department. The current study involved screening of 100 prescriptions, which belongs to 65 male and 35 female, out of which 27 prescriptions belongs to the age group of 41 - 50 years of age. Total numbers of drugs screened were 410 out of 100 prescriptions. The DDI's was assessed eventually in comparison with Stockley's, Medscape and BNF respectively based on the rating, severity and significance, and inferences. The main drug classes of DDI's were aminoglycoside gentamicin, ARB's, antacids, aspirin as analgesics, calcium channel blockers, beta blockers and NSAID's. In conclusion, In conclusion, the drug-drug interactions assessed in our study was majorly on 07 category of medications resembling in comparison to three standard international medications compendia but with certain considerable lack in ratings and severity of DDI's of other include drugs, which be rectified by continuous Continuing Medical Education (CME's) and series of advance learning with expertise on drug and its uses, preparing Hospital Formulary with extensive literature survey.

Keywords: Clinical decisions, drug information compendia, drug interactions, severity.