OROXYLUM INDICUM AND BAICALEIN: INTEGRATING TRADITIONAL MEDICINE, PHARMACOLOGICAL INSIGHTS, AND PERSONALIZED THERAPEUTIC STRATEGIES

Dr. Renu Chaudhary*, Dr. Sanjeev Kumar, Ranveer Singh and Mohd. Irshad

ABSTRACT

Oroxylum indicum, known as the Indian Trumpet Flower or Sonapatha, is a medicinal plant utilized in traditional medicine systems including Ayurveda and Traditional Chinese Medicine. Its therapeutic applications are diverse, encompassing the treatment of digestive disorders, respiratory issues, inflammatory conditions, and wound healing. The plant's major bioactive compound, baicalein, found in the roots and bark of Oroxylum indicum, has garnered significant interest for its broad spectrum of pharmacological activities. Baicalein exhibits anti-inflammatory, antioxidant, anticancer, and neuroprotective effects. However, its clinical efficacy is limited by challenges related to solubility, permeability, metabolism, and bioavailability. This review provides a comprehensive overview of the traditional uses of Oroxylum indicum, the pharmacological properties of baicalein, and the biopharmaceutical challenges associated with its use. Strategies to enhance baicalein’s solubility and bioavailability are discussed, including the development of novel delivery systems such as solid lipid nanoparticles, polymeric nanoparticles, liposomes, and self-emulsifying drug delivery systems. Furthermore, personalized medicine approaches, including pharmacogenomics, biomarker identification, disease pathology-based treatment, and personalized dosing, are explored to optimize baicalein's therapeutic potential. By addressing these aspects, future research can overcome existing limitations and enhance the clinical application of baicalein, paving the way for more effective and individualized therapeutic strategies.

Keywords: Oroxylum indicum, Baicalein, Traditional Medicine, Pharmacological Properties, Bioactive Compounds, Personalized Medicine.