NEURO DEGENERATION OF ACETYLCHOLINE IN SYNAPTIC CLEFT CAUSE ALZHEIMER DISEASE

Dibyendu Dutta*, Jaydeep Roy, Falguni Dutta, Rahul Kumar Singh, Rishav Banerjee and Dhrubo Jyoti Sen

ABSTRACT

As brain cells become affected, there's also a decrease in chemical messengers (called neurotransmitters) involved in sending messages, or signals, between brain cells. Levels of one neurotransmitter, acetylcholine, are particularly low in the brains of people with Alzheimer's disease. Acetylcholine (ACh), a neurotransmitter essential for processing memory and learning, is decreased in both concentration and function in patients with Alzheimer's disease. There is widespread loss of acetylcholine and other neurotransmitters in Alzheimer's disease and vascular dementia. Alzheimer's disease damages cells that produce and use acetylcholine. Certain medications can increase levels of acetylcholine. They do this by blocking the action of enzymes that break down the neurotransmitter. Acetylcholine is a neurotransmitter that plays a role in memory, learning, attention, arousal and involuntary muscle movement. Medical conditions associated with low acetylcholine levels include Alzheimer's disease and myasthenia gravis.

Keywords: Acetylcholine, Synaptic cleft, Neurotransmitter, Alzheimer disease, Dementia, Tau protein.