MEDICINAL PROPERTY OF VINCA ALKALOID AND THEIRIMPACT ON HUMAN HEALTH

Diksha Sharma*, Sumeet Choudhary and Kapil Kumar Verma

ABSTRACT

Vinca alkaloids, which are strong substances obtained from the Vinca rosea plant and are well-known for their important role in the treatment of cancer, include vincristine and vinblastine. These alkaloids cause cell cycle arrest and apoptosis in rapidly dividing cancer cells by interfering with the production of microtubules, an essential step in cell division. The field of oncology has changed significantly since its introduction into clinical practice, especially in terms of how leukemia, lymphoma, and other solid malignancies are managed. Notwithstanding their therapeutic advantages, vinca alkaloids have adverse effects that can impair patient quality of life and make treatment plans more difficult, such as peripheral neuropathy, constipation, and myelosuppression. The proper ratio of toxicity to efficacy is still a major area of ongoing study. The goal of medication distribution and combination therapies is to increase vinca alkaloids' therapeutic index while reducing side effects. Through innovative medication formulations and delivery methods, recent developments seek to maximize the effectiveness of vinca alkaloids while reducing adverse effects. These developments could lead to better patient outcomes and a wider range of vinca alkaloids' clinical uses. Overall, research is still being done to maximize the therapeutic potential of vinca alkaloids and reduce any related hazards, since they continue to be an essential part of cancer chemotherapy.

Keywords: Alkaloids, Leukemia, Essential, Production, Significantly, Treatment, Toxicity, Advantages.