SEPSIS-INDUCED COAGULOPATHY: ADVANCES IN DIAGNOSIS, PATHOPHYSIOLOGY, AND EMERGING THERAPEUTIC STRATEGIES: REVIEW OF LITERATURE

Dr. Abdul Latif Qureshi*, Dr. Mohammad Rafiq Khilji**, Dr. Neeraj Salhotra***

ABSTRACT

Sepsis-induced coagulopathy (SIC) significantly contributes to morbidity and mortality in septic patients, with
disseminated intravascular coagulation (DIC) being a major predictor of sepsis-related deaths. This review explores
recent advances in SIC diagnosis, pathophysiology, and emerging therapeutic strategies. Early recognition of SIC
is crucial, as it increases mortality by up to 40%. Simplified SIC criteria have enhanced early detection, allowing
timely intervention. Novel therapies, including recombinant thrombomodulin and antithrombin, have demonstrated
potential in modulating coagulopathy, reducing mortality by approximately 13% in clinical trials. Global disparities
in SIC management persist, particularly in low-resource settings, due to limited access to diagnostic tools and
advanced therapies. Strategies such as implementing affordable point-of-care diagnostics and training programs are
proposed to improve outcomes. This review also addresses ethical considerations, study limitations, and future
research directions, highlighting the need for personalized approaches and standardized global guidelines to
improve patient outcomes.

Keywords: Sepsois induced coagulopathy.