FREQUENCY OF SUBCLINICAL THYROID DISORDERS IN WOMEN OF REPRODUCTIVE AGE GROUP WITH DYSFUNCTIONALL UTERINE BLEEDING

*Dr. Asma Arshid, Dr. Aimen Mahmood, Dr. Khansa Iqbal

ABSTRACT

Introduction: Irregularities in the menstrual cycle may accompany or precede clinically overt thyroid dysfunction. Many studies have proved that menorrhagia is more commonly associated with hypothyroidism whereas an ovulation or oligo - menorrhea is common in Hyperthyroidism. Thyroid function test should be routinely investigated in patients presented with DUB in outpatient department to avoid unnecessary invasive procedures. Objectives: To determine the frequency of subclinical thyroid dysfunction among patients of menstrual irregularities. Study Design: Cross Sectional Study. Study Duration: 20th Jan 2022 to 19th July 2022. Settings: Department of Obstetrics and Gynaecology, Unit II, Holy Family Hospital, Rawalpindi. Materials and Methods: A total of 340 patients with menstrual disturbance of age 18 - 45 years were included. Presence of Palpable Pelvic Pathology, having known Thyroid Disorders, on Drugs like Aspirin, Heparin, Steroids, Amiodarone, Lithium, intrauterine contraceptive devices (IUCS) users, with symptoms of thyroid dysfunctions and on thyroid replacement therapy were excluded. Participants of the study were interviewed for menorrhagia oligomenorrhea, and amenorrhea. Detailed menstrual history and history associated with symptoms of Hypothyroidism and hyperthyroidism was taken. Participants were also clinically examined including GPE, Gentle abdominal, speculum and pervaginal examination. 5mg of venous blood was taken a plain glass tube without any anticoagulant. Morning sample in the fasting state was taken and serum was estimated for TSH, Free T3, Free T4. Results: Age range in this study was from 18 to 45 years with mean age of 28.06 ± 4.70 years. Majority of the patients 254 (74.71%) were between 18 to 30 years of age. Mean TSH levels were 4.49 ± 2.21 mI U/l. Frequency of subclinical thyroid dysfunction among patients of menstrual irregularities was found in 95 (27.94%) patients. Conclusion: This study concluded that frequency of subclinical thyroid dysfunction among patients of menstrual irregularities is very high.

Keywords: Dysfunction uterine bleeding, subclinical thyroid dysfunction, menorrhagia.