TRANSCUTANEOUS APPLICATION OF MAGNESIUM SULFATE IN THE TREATMENT OF CHRONIC NERVE AND MUSCLE PAIN

Chu J.*, Bruyninckx F. and Goodman S.

ABSTRACT

Pain is one of the most complex and unpleasant sensory and emotional human experiences. Pain relief continues to
be a major medical challenge. Magnesium sulfate (MgSO4), the pharmacological form of magnesium, is a
physiological voltage- dependent blocker of N-methyl-D-aspartate (NMDA)-coupled channels. In terms of its
antinociceptive role, magnesium blocks calcium influx, which inhibits central sensitization and decreases
preexisting pain hypersensitivity. Intravenous magnesium sulfate, followed by a balanced analgesia, decreases
opioid consumption.[1]

Keywords: .