IMPURITIES SYNTHESIS AND FORMULATION DEVELOPMENT OF ASPIRIN IMPURITES

Kavya V.*, Vedashree M., Bhagyashree K. C., Kavyashree S. B. and Kawaljeeth Singh

ABSTRACT

A design and synthesis of Aspirin is one of the most frequently used and cheapest drugs in medicine. It belongs to the non-steroidal anti-inflammatory drugs (NSAIDs) with wide range of pharmacological activities like analgesic, antipyretic, anti-inflammatory and antiplatelet properties. During the process of Aspirin preparation, formation of various impurities was observed. Which may show anti-inflammatory effect on cell. Although, the structure and analytical procedures of these impurities have been already reported in the literature. In the present investigation, Aspirin impurities like Aspirin Impurity A, Aspirin Impurity B, Aspirin impurity D, Aspirin Impurity E, Aspirin Impurity F. The anti-inflammatory activity of the synthesized impurities of Aspirin were evaluated by using in-vitro method. Topical gels have advantages in the formulation to circumvent the first pass effect, to improve its bio availability, to reduce dosing frequency and dose related side effects. Salicylic acid are formulated as topical gels which is used as the keratolytic or anti-inflammatory agent. Topical gels of salicylic acid is a BCS class I drug were prepared by fusion method and characterized by testing for spreadability, viscosity, surface pH, drug content uniformity.

Keywords: Aspirin API, Aspirin impurities, Synthesis, topical gel.