EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

CHARACTERIZATION AND EVALUATION OF ANTIPYRETIC ACTIVITY OF ALTERNANTHERA BRASILIANA (L.) KUNZTE ETHANOLIC LEAVES EXTRACT

Unnimaya I. S.*, Dr. G. N. Pramodini, Dr. D. Vijay Kumar and Dr. Sapna Shrikumar

ABSTRACT

Alternanthera brasiliana (L) Kuntze Amaranthaceae is A herbaceous plant used against inflammation, cough, and diarrhea in Brazilian popular medicine. It is a well-known plant rich in phytoconstituents. In the present work deals with the spectroscopic characterization and evaluation of in-vivo Antipyretic activity of ethanolic leaves extract of Alternanthera brasiliana (L) Kuntze. Spectroscopic analysis by FTIR revealed the presence of flavoids especially quercetin, through the appearance of intense bands at specific areas. Antipyretic activity of ethanolic extract of Alternanthera brasiliana (L) Kuntze leaves were evaluated using yeast induced pyrexia model. At the dose 200 mg/kg of ethanolic extract shows significant reduction in body’s temperature (p>0.05) was observed in the temperature of rats tested.

Keywords: Alternanthera brasiliana (L.) Kuntze, Flavonoids, Ethanolic extract, FTIR, Antipyretic activity.

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EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH