MULTIMODAL SERUM BIOMARKERS FOR PREECLAMPSIA PREDICTION AND RISK ASSESSMENT: THE ROLE OF PROTEIN, ALBUMIN, CREATININE, AND URIC ACID

Khushboo Pal*, Soobia Karim Ansari and Rudra Pratap Ojha

ABSTRACT

Background: Preeclampsia is a pregnancy-related illness characterized by high blood pressure and damage to organs such as the liver and kidneys. When preeclampsia is present, serum proteins, albumin, creatinine, and uric acid are often measured. All cells and tissues require proteins as building blocks. Proteins are crucial to the growth, development, and health of the fetus as well as the expectant mother during pregnancy. Objective: The goal of the current study was to evaluate whether liver and kidney function tests might be utilized as markers to predict pregnancy-induced hypertension (PIH) and to highlight the possible roles that protein, albumin, creatinine, and uric acid may play in women with pre-eclampsia (PE). Material and Methods: The present study was under taken in 100 healthy pregnant women and 100 pre-eclampsia pregnant women of age group between 19-40 years during second trimester of pregnancy. Pregnant women who were pre-eclamptic had greater blood pressure than the control group (P < 0.001). In 200 pregnant women, serum protein and albumin were determined using a standardized test using kit procedures. When compared to the controls, pre-eclamptic pregnant women had a clinically significant proteinemia status. RFTs, such as the Infinite Diagnostic Kit method for measuring uric acid and the CRTN in vitro Diagnostic Kit method for measuring creatinine. Results: Compared to controls, pre-eclamptic pregnant women had considerably higher levels of creatinine and uric acid (10.862% and 44.19%), although blood protein and albumin levels were significantly lower (9.30% and 17.47%).

Keywords: Pre-eclampsia, hypoproteinemia, creatinine, and uric acid.