“PHARMACOGNOSTICAL, PHYTOCHEMICAL AND INVITRO BIOLOGICAL EVALUATION OF ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF THE MELIA DUBIA”

Dr. L. Shiju, Bhoomika S.*, Manoj M., Raju G. N., Saba Noorain and Joyal Antony

ABSTRACT

India has a rich traditional of plant based knowledge in health care. Among the large number of herbal drug existing in india, very few have been studied systematically so far, The study on Melia dubia, a native Indian tree, focused on evaluating its medicinal properties, particularly its antioxidant and antidiabetic activities. The leaves, collected from the Mandya region, were analyzed for various phytochemical constituents including alkaloids, carbohydrates, steroids, tannins, flavonoids, saponins, and glycosides. Thin layer chromatography (TLC) was used to detect biomolecules in the methanolic extracts. The research found that the ethanolic extract of Melia dubia exhibited significant antioxidant and antidiabetic activities. Specifically, the methanolic extract demonstrated effective α-amylase inhibition at lower concentrations compared to the standard drug Acarbose. Dditionally, the antioxidant activity of the extracts was notably high, likely due to the high levels of phenolic and flavonoid compounds in the methanolic fraction. These findings suggest that Melia dubia holds potential for development into plant-based medicines, leveraging its natural bioactive compounds for therapeutic purposes.

Keywords: Melia dubia, anti-oxidant and anti-diabetic activity.