ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITY OF SCHIFF-BASE DERIVATIVES CONTAINING BENZIMIDAZOLE MOIETY

Irfan N. Shaikh,*, Umar Farooq Bagwan, Mahantesh M. Kurjogi, Kallappa M. Hosamani,

ABSTRACT

A new class of Schiff base derivatives containing benzimidazole moiety were screened for their potential antimicrobial and anti-inflammatory properties. Some of these derivatives showed moderate to potent in-vitro antimicrobial and in-vivo anti-inflammatory activities. The results revealed that, Compound a12 and a20 exhibited the most potent antibacterial activity with lowest MIC value against S. aureus and E. coli. While compounds a12, a14, a17, and a18 showed excellent antifungal activity when compared with standard drugs. Compounds a12, a14, a15, a17, a18 and a20 were found to be the main structural requirement for maintaining anti-inflammatory activity.

Keywords: Schiff’s Base, Benzimidazole derivatives, Antimicrobial, Anti-inflammatory.