DEVELOPMENT AND CHARACTERIZATION OF METOCLOPRAMIDE HOLLOW MICROSPHERES

Amreen Fatima*, Niloufer Tasnim Khazi and Bibi Fareesa Banu

ABSTRACT

This study aims to develop and characterize hollow microspheres of metoclopramide designed for enhanced absorption in gastric pH conditions. The microspheres were prepared using an emulsion solvent diffusion method with polymers such as sodium alginate, ethyl cellulose, and carbopol 934. Key parameters like buoyancy, yield percentage, drug entrapment efficiency, and in vitro drug release were evaluated. Characterization through FT-IR confirmed no significant drug-polymer interactions, and SEM analysis revealed a smooth, dense external surface with a porous interior, prolonging the microspheres' floating capacity. In vitro release studies demonstrated controlled drug release over an 8-hour period, indicating that the hollow microspheres are suitable for gastroretentive drug delivery of metoclopramide, potentially enhancing patient compliance and therapeutic efficacy.

Keywords: Metoclopramide, Hollow microspheres, Controlled release, Gastroretentive, Emulsion solvent diffusion, Drug delivery.