EVALUATION OF ANTIOXIDANT AND HEPATOPROTECTIVE POTENTIAL OF FERONIA LIMONIA IN RATS

Absar A. Qureshi* and K. Eswar Kumar

ABSTRACT

Prophylactic and curative hepatoprotective property of suspension of Feronia limonia fruit was studied against PCM induced hepatic damage in albino rats. Pre and post treatment with SFL, before and after PCM treatment reduced the biochemical markers of hepatic damage like SGPT, SGOT, serum ALP, serum cholesterol, total and direct bilirubin and tissue GSH. Histopathological studies also revealed that pre and post treatment with SFL, before and after PCM treatment protected the liver from PCM induced liver damage. In addition an antioxidant study was carried out by in vitro lipid peroxidation. In the present study it has been found that prophylactic study showed better hepatoprotection than curative activity.

Keywords: Antioxidant, Feronia limonia, hepatoprotection, paracetamol.