INNOVATIVE APPROCHES USED INGASTRORETENTIVE DRUG DELIVERY SYSTEMS: A REVIEW

Sakshi R., Y. Anand Kumar and K. M. Lokamatha Swamy*

ABSTRACT

Pharmaceutical research has recently placed significant emphasis on the development of gastroretentive oral drug delivery systems (GRDDS) to improve drug bioavailability and efficacy. Gastric retention helps to provide better availability of new products with suitable therapeutic activity and substantial benefits for patients. This mode of administration is ideal to achieve known pharmacokinetic and pharmacodynamic advantages of various categories of drugs. These systems have been designed to address the challenges associated with drugs that are unstable in alkaline pH, soluble in acidic pH, have a limited absorption window, and target specific sites within the stomach. Consequently, a diverse range of dosage forms has emerged, catering to these requirements. Various innovative approaches have been employed in the development of GRDDS, which are discussed in this review. These approaches include the use of novel polymers, such as hydrogels and nanoparticles, as well as the incorporation of stimuli-responsive components, such as pH-sensitive and temperature-sensitive materials. Additionally, the utilization of advanced manufacturing techniques, such as 3D printing, has enabled the creation of complex and personalized drug delivery devices. Furthermore, it explores the various applications of these systems in the field of pharmacy and includes a comparative diagrammatic representation to highlight their key features.

Keywords: Gastroretention, GRDDS, Bioavailability, gastric emptying, 3D printing, controlled release.