DENSITIES AND APPARENT MOLAR VOLUME OF BENZIMIDAZOLE IN PURE & BINARY SOLVENT MIXTURES OF N-PROPANOL + WATER

*Sachin S. Kale

ABSTRACT

Benzimidazole is an important pharmacophore in medicinal chemistry. Benzimidazoles are having a many therapeutic uses like antibacterial, antifungal, analgesics, antitumor, antiparasitic, antihistamine, and antiviral. Using bicapillary pycnometer densities of Benzimidazole in n-propanol with water were measured over the entire composition range at temperatures from 293.15 to 313.15 K. Densities of the saturated solution of benzimidazole in a pure and binary mixture of solvents were measured at mentioned temperature. This density data was used to calculate apparent molar volume. The apparent molar volume (𝛷v) values for all solutions in pure solvents or in mixed solvent increases with the increase of temperature. The density of benzimidazole in pure water solution decreases slightly with the increase in temperature but for pure n-propanol solution it increases with increase in temperature.

Keywords: Benzimidazole, n-propanol, Density, Apparent molar volume.