THE MANAGEMENT AND POTENTIAL ROLE OF PROBIOTICS IN GASTRIC ULCER: A REVIEW

Sumit Kumar Dhore*, Dr. Vishal Dubey and Megha Tiwari

ABSTRACT

One of the most common chronic gastrointestinal disorders, gastric ulcers, is characterised by a compromised mucosal barrier. Chronic usage of non-steroidal anti-inflammatory medicines (NSAIDs) and Helicobacter pylori (H. pylori) infections are two of the main causes of ulcer development. Usually, acid-suppressing drugs and antibiotics are used in treatment. Additionally, probiotics are being investigated as a possible therapy and preventative strategy for stomach ulcers, but, as a result of mounting evidence of antibiotic resistance as well as adverse effects from both antibiotics and acid-inhibiting medications in recent decades. Probiotics are now showing promise for use in the treatment of stomach ulcers, according to experimental and clinical investigations. This article offers a summary of the wider health advantages of probiotics on a range of gastrointestinal and systemic illnesses, with a focus on stomach ulcers and the underlying cellular and molecular processes. Probiotics support angiogenesis, improve the balance between cell proliferation and death, boost the synthesis of prostaglandins, mucus, growth factors, and anti-inflammatory cytokines, and help preserve the stomach mucosal barrier. The paper also looks at data that suggests probiotics may be used to eradicate H. pylori.

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