FORMULATION AND EVALUATION OF FLOATING TABLETS WITH GLYCYRRIZHA GLABRA
Sandhya Karumanchi* and Dr. A. Pavani
ABSTRACT
Herbal products are valued for their natural properties, lack of side effects, and affordability, making them beneficial for people across various countries. Considering these advantages, herbal plants were selected for this study. Licorice, a traditional medicinal herb, is widely used for treating ulcers. This study aimed to develop and evaluate herbal floating tablets containing Licorice extract (Glycyrrhiza glabra). The extract was prepared using maceration, in which Licorice was soaked in a 30:70 ethanol-water mixture for seven days. Afterward, the mixture was filtered, and the extract was dried in an oven before being stored in an airtight container for future use. The tablets were developed using a direct compaction technique, using Licorice extract along with polymers such as xanthan gum, sodium alginate, guar gum, and HPMC K15, as well as excipients like magnesium stearate, talc, and microcrystalline cellulose. The formulations were tested for properties including width, solidity, mass consistency, friability, suspension time, and dissolving rate. Optimization of the formulations focused on floating time and laboratory drug release. The tablet thickness ranged from 5 to 5.4 mm, while hardness varied between 6 and 6.4 kg/cm². All preparations met the USP standards for the tendency to break and weight uniformity. All tablets achieved a buoyancy time of under 5 minute and remained afloat for this entire study duration. This optimized formulation, FS3, demonstrated a drug release of 71.2% over 8 hours in vitro, with an initial buoyancy time of just 20 seconds. Each tablet formulation was successfully prepared.
Keywords: Floating tablets, Licorice extract, different polymers, antiulcer activity.
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