MICROWAVE ASSISTED SYNTHESIS OF 1-FORMAMIDINO-3-SUBSTITUTEDFORMAMIDINOTHIOCARBAMIDES

D. T. Tayade and S. P. Ingole*

ABSTRACT

One pot three component synthesis by non-conventional synthetic method has been carried out recently in this laboratory for the synthesis of 1, 3-diformamidinothiocarbamide and a series of 1-formamidino-5-substitutedformamidinothiocarbmides (IIIa-e) by the interactions of cyanoguanidine (I), concentrated hydrochloric acid and various thiourea (IIa-e) by making use of microwave irradiation. This synthetic method has revealed extensive applications as it is very efficient way to accelerate the course of many organic reactions, producing high yields, higher selectivity and lower quantities of side products consequently easier work-up and purification of the products.

Keywords: Substituted thiourea, cyanogaunidine, microwave.