CHONDROSARCOMA OF LARYNX: A CASE REPORT WITH REVIEW OF LITERATURE

Dr. Mohamed H. M. Ali, Dr. Mohammed Ahmed Abd Allah*, Dr. Wisal Ahmed Abd Alla Hussein, Dr. Salma Suleiman Hassan, Omer Mohamed Omer Mohamed, Hanadi Elsir Mohamed Ahmed, Lobna E. Ali, Eman Hassan Mohammed Ali and Abubaker Awad Khiery

ABSTRACT

Background: Laryngeal chondrosarcoma is a rare malignant tumor of the larynx, characterized by its unique clinical presentations and histopathological features. makes up only about 0.2% of all head and neck malignancies and approximately 1% of all laryngeal tumors. Case Presentation: We present a case of a 65-year-old male with high-grade chondrosarcoma of the larynx, who exhibited a 2-month history of progressive voice changes without significant systemic symptoms. Histopathological Findings: Histopathological evaluation revealed a high-grade chondrosarcoma with pleomorphic nuclei, high mitotic activity, and a cartilaginous matrix. The findings indicated an aggressive tumor behavior, prompting concerns for local invasion and recurrence. Interpretation and Conclusion: The clinical presentation, imaging, and histopathological findings in this case align with the literature on laryngeal chondrosarcoma. Compared to other reported cases, the aggressive nature of this tumor underscores the variability in clinical outcomes based on tumor grade and surgical margins.

Keywords: Cartilage, Chondrosarcoma, Larynx.