SMALL DENSE LOW DENSITY LIPO-PROTEIN AND CORONARY ARTERY DISEASE: A STUDY IN A TERTIARY CARE CENTRE IN EASTERN INDIA.

Sharmistha Chatterjee*, Dr.Biswajit Majumder, Dr.Vijayan Ganesan, Dr.Partha Sarathi Karmakar

ABSTRACT

Ischaemic heart disease (IHD) is projected to be the most important cause of mortality worldwide by 2020.[1] The prevalence of coronary artery disease (CAD) is very high in the population residing in the South East Asian countries, particularly, among the male sex.[2,3] The major independent risk factors for CAD are advancing age, elevated blood pressure, elevated serum total and LDL cholesterol levels, low serum HDL cholesterol level, diabetes mellitus, and cigarette smoking. While the importance of low-density lipoprotein (LDL) cholesterol in the development of atherosclerosis cannot be over-emphasised, recent research activity has shifted the focus on the heterogeneity of LDL particles, particularly with regard to differences in lipoprotein composition, size and metabolism.[4] Of these, the biochemical characteristics of small dense LDL (sd-LDL) appear to be of paramount importance in the pathogenesis of CAD. Sadly, there appears to be a dearth of studies co-relating sd-LDL and CAD in this part of the country. Therefore, it was deemed worthwhile to undertake a study to estimate the levels of sd-LDL in patients presenting with acute coronary syndrome (ACS) attending a tertiary care hospital in Eastern India.

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