EVALUATION OF ANTIDIABETIC ACTIVITY ON LEAVE OF MOMORDICA CHARANTIA ON EXPERIMENTAL ANIMAL

Aishwarya Singh*, Praveen Kumar and Shamim Ahmad

ABSTRACT

Studying how Momordica charantia leaf extract mitigates streptozotocin-induced diabetes in Wistar rats is the focus of this investigation. Two groups of streptozotocin-induced diabetic rats were given different dosages of Momordica charantia extract orally: 200, 300, and 350 mg/kg. Following a 40-day course of treatment, important parameters including lipid profile, glycosylated hemoglobin, body mass index, and blood glucose levels were assessed. This study's findings show that Momordica charantia extract significantly reduced levels of glucose, glycosylated hemoglobin, triglycerides, cholesterol, LDL, VLDL, blood urea, and other markers of lipid profiles (p < 0.05). In comparison to the diabetic control group, both therapy groups showed improvements in body weight and HDL values. The results showed that the Momordica charantia leaf extract was very effective in reducing blood sugar levels and lowering cholesterol in rats, whether the rats were naturally diabetic or had been forced to become diabetic by streptozotocin.

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