EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

FORMULATION AND EVALUATION OF VORICONAZOLE SUSTAINED RELEASE TABLETS

A. Vipul Kumar Reddy* and Dr. A. Yasodha

ABSTRACT

The aim of the present study was to develop sustained release formulation of Voriconazole to maintain constant therapeutic levels of the drug for over 12 hrs. HPMC-E15, Carbopol 934, Eudragit, Sodium Alginate were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F11) showed better and desired drug release pattern i.e., 99.98% in 12 hours. It contains the Eudragit 1:3 as sustained release material. It followed Peppas release kinetics mechanism.

Keywords: Voriconazole, HPMC-E15, Carbopol 934, Eudragit, Sodium Alginate, Sustained release system.


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SJIF Impact Factor: 7.065

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