EVALUATION OF ANALGESIC AND ANTIOXIDANT ACTIVITY OF LEAVES EXTRACT OF XANTHOSOMA SAGITTIFOLIUM

Anuj Kumar Sharma*, Praveen Kumar and Shamim Ahmad

ABSTRACT

The present study investigates Xanthosoma sagittifolium leaf phytochemical composition, acute toxicity, analgesic characteristics, and antioxidant activities. Bioactive chemicals including alkaloids, anthraquinone glycosides, proteins, amino acids, carbs, saponins, flavonoids, phenols, and lipids were identified in the phytochemical study of the ethanolic leaf extract. There were no fatalities at dosages up to 2000 mg/kg in acute toxicity studies that followed OECD standards, indicating a safe LD50 within Category 4 (300-2000 mg/kg) of the Global Harmonized System (GHS). At 100, 200, and 300 mg/kg, the tail-flick method demonstrated significant analgesic effects that were dose-dependent for both the methanolic and ethanolic extracts. There was a notable uptick in antioxidant markers such as glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) levels after therapy, indicating that the treated groups experienced less oxidative stress. Research conducted here confirms that X. sagittifolium contains natural analgesic and antioxidant chemicals, lending credence to its long history of use in traditional medicine and suggesting that it may be useful in treating pain and diseases associated with oxidative stress.

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