A REVIEW ON ADVANCED AND CHALLENGES IN OCULAR DRUG DELIVERY SYSTEMS

Rahul Patil*

ABSTRACT

Eye conditions that are frequently encountered in daily life can be prevented or treated with routinely used dosage forms, such as eye drops and ointments. Because of the eye's protective and anatomical structure, delivery to the internal components of the eye is still problematic. One of the most intriguing and difficult issues facing pharmaceutical firms today is ocular medication delivery. The primary issue with traditional dose regimens is the drug's bioavailability. In-situ-forming ophthalmic drug delivery systems made from polymers that display reversible liquid-gel phase transition can overcome the poor bioavailability of ophthalmic solutions brought on by dilution and drainage from the eye. To address these issues, other kinds of dosage forms, including liposomes, nanoparticles, and There are now micro emulsions available. In terms of increasing medication bioavailability, lowering toxicity, and lowering dosing frequency, controlled drug delivery systems are superior to traditional dosage forms in many ways. More recent studies on ophthalmic drug delivery systems focus on combining multiple drug delivery technologies, such as build-up systems that slow down the drug's removal while simultaneously extending the vehicle's contact time at the ocular surface. This review concentrates on new advancements in both traditional and unconventional ocular dose formulations and items that extend medication contact times. contact the cornea, improve their bioavailability, and use various goods and techniques for both delivery methods.

Keywords: Ophthalmic drugs, nanoparticles, eye drops, micro-emulsions, ointments.