CHITOSAN NANOPARTICLES: VERSATILE CARRIERS FOR DRUG DELIVERY AND BEYOND

Shaharban K.*, Sijo Pattam, Muhammed Harshad P. and Muhammed Sajir K.

ABSTRACT

Chitosan nanoparticles have emerged as a promising platform for drug delivery due to their unique properties such as biocompatibility, biodegradability, and mucoadhesive nature. Derived from chitin, these nanoparticles offer significant advantages in improving drug solubility, permeability, and targeted delivery. By leveraging their ability to crosslink with anions and interact with cell membranes, CSNPs enable controlled and sustained drug release while enhancing therapeutic efficacy. Various synthesis methods, including ionic gelation and emulsification, have been explored to optimize their applications across diverse biomedical fields. This review delves into the preparation techniques, advantages over other systems, and their potential for site-specific drug delivery.

Keywords: Chitosan nanoparticle, controlled release, drug delivery, biocompatibility, ionic gelation.