FORMULATION AND CHARACTERIZATION OF ETODOLAC LOADED EMULGEL FOR TOPICAL DRUG DELIVERY APPROACH

Jalappa D. Biradar*, Vijay Kumar and Roopam Devaliya

ABSTRACT

Etodolac, a non-steroidal anti-inflammatory drug (NSAID), is valued for its analgesic, anti-inflammatory, and anti-arthritic properties. However, its therapeutic potential is limited when administered orally due to its poor water solubility and extensive first-pass metabolism in the liver. These issues lead to reduced bioavailability, requiring higher doses to achieve desired effects, which can cause erratic drug plasma levels and increase the risk of gastrointestinal side effects like irritation and toxicity. To overcome these challenges, alternative drug delivery methods such as topical administration offer a more targeted approach. Topical delivery allows the drug to bypass the gastrointestinal tract and hepatic metabolism, avoiding first-pass effects and potentially improving bioavailability. Additionally, this method allows for localized drug action, providing direct relief at the site of inflammation or pain, which is particularly advantageous for conditions such as arthritis.

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