EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

AN EFFICIENT ULTRASOUND ASSISTED ASPARTIC ACID CATALYZED MULTICOMPONENT SYNTHESIS OF ISOXAZOLE-5(4H)-ONES

Quadri Maqsood Ahmed and Maqdoom Farooqui*

ABSTRACT

A green and efficient protocol was developed for the multicomponenet synthesis of isoxazoles via the Ethanol:water mediated multicomponent reaction of aromatic aldehyde, ethyl acetoacetate, and hydroxylamine hydrochloride in ultrasonic conditions catalyzed by aspartic acid at ambient conditions. It is noteworthy that the aspartic acid promoted one-pot three-component process under ultrasonic conditions was observed to be very good and satisfactory.

Keywords: Isoxazole, Aspartic acid, Ultrasound.


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SJIF Impact Factor: 7.065

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