ADVANCEMENTS IN NANO-FORMULATION SYSTEMS FOR ENHANCING THE DELIVERY OF HERBAL INGREDIENTS

Mahmoud Mahyoob Alburyhi*, Amina El-Shaibany, Asma Mohsen Al-Wajih, Anas Ahmed Alqadhi and Aiz-Aldean Naser Almlhani

ABSTRACT

The development of novel drug delivery systems (NDDS) has become crucial in overcoming the challenges posed by poor water solubility and bioavailability of newly formulated drugs, including herbal compounds. This research reviews various nanoformulation systems designed to enhance the delivery and efficacy of herbal active ingredients. We explore several cutting-edge nanotechnology-based systems, such as liposomes, transferosomes, niosomes, ethosomes, phytosomes, and nanoparticles. Each system offers unique advantages, including improved solubility, stability, and targeted delivery, addressing limitations of conventional dosage forms. Liposomes and phytosomes, for instance, significantly enhance the solubility and bioavailability of herbal compounds, while ethosomes and transferosomes improve skin permeation and drug delivery. The study also examines the effectiveness of nanoparticles and nanoemulsions in providing controlled release and increased therapeutic indices. By integrating these advanced delivery systems, researchers aim to maximize the therapeutic potential of herbal medicines and overcome the limitations faced in clinical applications.

Keywords: Nanoformulation, Herbal Active Ingredients, Liposomes, Transferosomes, Niosomes, Ethosomes, Phytosomes, Nanoparticles, Bioavailability, Drug Delivery Systems.