RESVERATROL IN TREATMENT OF CANCER: MACHANISM, EFFICACY AND FUTURE DIRECTION

Shiddhesh Chavan*, Suresh Waghmare, Nikita Chondhe, Pranjal Lahare and Payal Durule

ABSTRACT

Resveratrol a polyphenolic compound primarily find in grapes, berries, and peanuts, has emerged as a promising agent in cancer research due to its potential anticancer properties. Pathway in a process similar to that of flavonoids. Resveratrol comes in both cis and trans isomeric forms, with trans-resveratrol seemingly being the more prevalent and stable natural form. It has two phenol rings (Monophenol and diphenol) joined by a double styrene link. Three hydroxyl groups in this molecule are engaged in metal chelation and free radical scavenging. Additionally, hydroxyl groups make it easier to interact with macro molecules. This article looks into the several ways resveratrol works to prevent cancer, such as by preventing the growth of cancer cells, causing them to die, and altering important signaling pathways such the PI3K/Akt and MAPK pathways. Preclinical research has state that resveratrol is effective against a number of cancer types, such as colorectal, prostate, and breast cancers, suggesting that used as an adjuvant treatment in addition to traditional therapy. Moreover, resveratrol has shown the ability to enhance the result of chemotherapeutic agents while reducing their associated side effects, indicating its dual role in improving therapeutic outcomes. Its impact on the tumor microenvironment, suppression of angiogenesis, and reduction of metastatic spread further accentuates its therapeutic promise. However, challenges such as low bioavailability and limited clinical data hinder its widespread application in oncology. This review emphasizes the need for rigorous clinical trials to assess the efficacy and safety of resveratrol in cancer treatment. By synthesizing current findings and identifying research gaps, this paper aims to provide a comprehensive overview of resveratrol's role as an anticancer agent. Ultimately, the insights gained could contribute to the increasing of innovative cancer treatment strategies, potentially improving patient outcomes and advancing the term of oncological pharmacotherapy.

Keywords: Natural compounds cancer therapy, Resveratrol experimental trials cancer, Resveratrol clinical trials cancer, chemo preventive, Polyphenols compound, cancer therapy.