ASSOCIATION OF CARDIAC BIOMARKERS WITH OUTCOME OF COVID-19 PATIENTS - A DESCRIPTIVE STUDY ATA TERTIARY CARE CENTRE IN INDIA

Dr. Nevil Patel*

ABSTRACT

Aim and Background: Coronavirus disease (COVID-19) is caused by Severe acute respiratory syndrome- Corona virus 2 (SARS-COV2) and represents the causative agent of a potentially fatal disease that has reached a pandemic level. Cardiovascular complications are common in COVID -19 patients like any other influenza virus and includes- myocarditis, acute myocardial infarction, and exacerbation of heart failure (HF), all contributing to increased mortality. This descriptive study aims to evaluate the incidence of cardiac biomarker elevation in symptomatic COVID -19 patients and the association of troponin/NT-proBNP (N-terminal pro-hormone Brain natriuretic peptide) levels with clinical outcome. Materials and methods: This was a hospital based retrospective study conducted at a Cardiology Unit of a tertiary care hospital. All patients admitted in past 6 months with diagnosis of COVID 19 were recruited. Duration of the study was of 1 month. Results: Among 131 patients 58% were males and 42% were females. 16.79% died during the study and 35.11% of patients were discharged from hospital. 42.75% of study population had severe form of COVID. 64.89% of patients required oxygen supplementation and 16.79% needed ventilator support for survival. 22.9% of patients had hypertension whereas 16.79% had diabetes as co morbidities. P values of patients needing oxygen requirement or ventilation is non-significant in all the categories. Conclusion: Our study showed no significant association between troponin and BNP values with the severity of Covid-19 disease. BNP values were raised in only 1-2 patients requiring oxygen and ventilator support. Large sample size is needed to confirm this study.

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