FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLET OF DOXAZOSIN MESYLATE FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA

N. Madhavi*, T. Nikhitha and T. Rama Rao

ABSTRACT

The objective of the present study was to develop sustained release tablets of Doxazosin Mesylate. The tablets were prepared by direct compression method the polyemer are used in the formulation are HPMC K-100, Xanthan gum and Ethyl cellulose with different ratios. The powder were evaluated for angle of repose, bulk density, compressibility index and drug content. The tablets were subjected to weight variation test, drug content, hardness, friability and in vitro drug release studies. The tablets showed satisfactory flow properties, compressibility and drug content. All the tablets formulation showed acceptable pharmacotechnical properties. The results of dissolution studies indicated that formulation DM4 drug and xanthan gum could sustained the drug release up to 12hrs.The most successful formulation of the study exhibited satisfactory drug release.

Keywords: Doxazosin Mesylate, sustained Release, Direct Compression Method.