TUMOR-ASSOCIATED INFLAMMATION MECHANISMS CORRECTION BY VERAPAMIL AT BRAIN GLIOMAS PROGRESSION

*Gridina N.Ya., Shvachko L.P. and Draguntsova N.G.

ABSTRACT

Brain gliomas progression was investigated indirectly through tumor-associated inflammation (TAI) mechanisms.[1-5] Diamine oxidase and polyamine oxidase enzymes activity decrease is result in healing incomplete as ―phenomenon persistent wound‖ at III stage of TAI. As a result of this phenomenon against a background of prolonged blood cells aggregation increasing is a significant blast cells accumulation. Increase of gene Snail expression level in blasts lead to epithelial - mesenchymal transition mechanism activation. Under dose of verapamil promote decreasing of blood cells aggregation, polyamines oxidation enzymes activity increasing, lymphocytes proliferate activity decreasing, gene Snail expression suppression in blast cells at TAI.

Keywords: brain gliomas, tumor - associated inflammation, verapamil, gene Snail.