COMPARISON AND ASSESSMENT OF VARIOUS BRANDS OF OFF-THE-SHELF OFLOXACIN TABLETS

Jalappa Biradar*, Gulam Ayyan Gulam Zaheer, Gunthe Balaji Dnyaneshwar, Gurdale Kiran Dilip, Hembade Sanjivani Tukaram

ABSTRACT

Ofloxacin, a synthetic antibiotic belonging to the second-generation fluoroquinolone class, is commonly used in chemotherapy for treating a variety of bacterial infections. It is highly effective against infections of the skin, respiratory tract, prostatitis, and mild to moderate urinary tract infections. Ofloxacin is also widely available as an over-the-counter (OTC) medication, particularly in treating bacterial infections in different parts of the body, including acute gastrointestinal infections. As a broad-spectrum antibacterial agent, Ofloxacin is active against both gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa, Enterobacteriaceae, and methicillin-resistant Staphylococcus aureus (MRSA). This study focuses on a comparative evaluation of different commercial brands of Ofloxacin tablets to assess their quality based on various physicochemical properties. Additionally, sustained-release formulations of Ofloxacin have gained research attention in recent years, particularly with an emphasis on extending gastric retention time (GRT). Improving GRT enhances therapeutic efficacy by allowing the drug to stay longer in the stomach, leading to better absorption and prolonged effects. The ultimate goal is to improve drug delivery systems, ensuring that medications remain in the gastrointestinal tract for an extended period, thus enhancing both the therapeutic impact and patient adherence.

Keywords: Ofloxacin tablets, Brand comparison, Pharmaceutical assessment, Drug quality analysis.