EXTENSIVE REVIEW OF SUNSCREEN AGENTS BY DOCKING STUDIES

Prof. Dr. Dhrubo Jyoti Sen*

ABSTRACT

Sunscreens which are widely used by almost every individual on every day basis is a key protector against sun damage and tanning. The damage is not limited to darkening of skin but it leads to carcinoma also. Thus sunscreen plays a major role in prevention of life threatening disease. But surprisingly the one which prevents carcinoma can create carcinoma in turn. Estrogens, progesterone and testosterone play an important role in the development of hormone-sensitive organs including the mammary gland. Exposures to estrogen and androgen receptors showing agonists and antagonists activity affect the growth of the mammary gland, its function and risk of disease during critical window of development. It is found that when the active ingredients bind with some receptors then they act as hormone disruptor. The main focus is onto how sunblockers can impose health hazards by binding with receptors. The binding energy shows how potent disrupting activity these compounds contain. These active ingredients bind effectively more with ERα than with Erβ. These ingredients applied topically not only remains on the skin but also it penetrates the skin and enters the blood stream and is excreted via urine and faeces. Moreover it is found that there is an increase in use of these compounds in various consumer goods as perfumes to enhance the fragrance to candies and other foods as a flavouring agent even at the same time it is used to protect food, beverages and various other consumer goods from degradation on exposure to sunlight. Thus it is found that due to excess exposure to these chemicals accumulation of these ingredients are found much more in blood and hence their effects are also found over period.

Keywords: Sunscreen, UVA & UVB, titanium dioxide, zinc oxide, avobenzone, oxybenzone, octinoxate, octisalate, autodoc vina.