AN EXTENSIVE REVIEW OF EMULGEL A STIMULI RESPONSIVE SYSTEM

A. Selvi and S. Rithick Raja*

ABSTRACT

The development of advanced drug delivery systems has gained significant attention for improving therapeutic efficacy and patient compliance. This study focuses on the formulation and evaluation of a ketoconazole-loaded emulgel with ph and thermosensitive stimuli-responsive properties. Ketoconazole, an antifungal agent, suffers from limited water solubility and bioavailability, which can hinder its therapeutic potential. To address these limitations, an emulgel formulation was designed using biocompatible polymers that respond to external stimuli, such as pH and temperature, to enhance drug release in targeted conditions. The formulation process involved optimizing the oil phase, emulsifiers, and gelling agents to ensure stability, ease of application, and controlled drug release. Comprehensive evaluation was performed, including physicochemical characterization, rheological analysis, in vitro drug release studies, and antifungal efficacy testings are to be caried out.

Keywords: Ketoconazole, Emulgel, Stimuli responsive formulation, Controlled drug release, Ph and Temperature sensitive.