DMBA-TPA-INDUCED MELANOMA CANCER AND ASSESSMENT OF THE PLANT EXTRACT OF BOSCIA SENEGALENSIS LEAF EXTRACT IN VIVO ANTI-MELANOMA ACTIVITY IN ANIMAL MODELS

Mohammed Adam Idris Hamad*, Dr. Mohamadmoin K. Modasiya Roshanjahan M. Modaysia and Dr. Rama Nargund

ABSTRACT

The potential of plant-based anti-cancer drugs targeting tumor locations has attracted considerable attention due to their potential advantages compared to conventional approaches. In particular, the BSL ointment formulation has shown promising results in decreasing the number of papilloma in vivo models. Application of Fu-5 to the study group of mice led to a decrease in the number of papillomas, and tumor promotion was observed upon the administration of DMBA-TPA to the skin of mice. Notably, the BSL group exhibited a significant decrease in papilloma, with the treatment group showing a substantial response compared to the control group. The application of BSL ointment did not significantly harm the liver, as indicated by the unchanged levels of ALT, AST, and ALP. The DMBA-TPA group exhibited an increase in liver parameters. P < 0.001, P < 0.004, P < 0.007, P < 0.004. The statistical data for the BSL extract treatment group further supports these findings, with significance indicators at P < 0.001, P < 0.002, and P < 0.006. These results highlight the promising potential of plant-based anti-cancer drugs, emphasizing the need for further research and development in this area.

Keywords: Skin cancer, DMBA-TPA, Boscia senegalensis.