HISTOLOGICAL AND PHYSIOLOGICAL EFFECT OF DOXOCYCLINE ON LIVER AND KIDNEY OF ALBINO RATS RATTUS RATTUS

Noor Ibrahim*

ABSTRACT

Background: Doxycycline (DOX), belonging to the tetracycline class of antibiotics, is commonly used to treat a range of bacterial infections and has shown notable clinical advantages. Furthermore, it possesses diverse effects, including anti-inflammatory and antioxidant properties. Objectives: The focuses of the consider is to Histological changes of doxocycline effect on liver and kidney and serum biochemical markers(AST, ALT, ALP, T.S.B) also urea and creatinine. Materials and Methods: This study included 30 albino rats, were utilized to total this consider. The rats were treated daily four weeks of treatment according to the following details: Healthy control group / (10) rats fed on standard diet only, (10)rats with oral administration by 50 mg/kg/ of doxycycline and (10) rats with oral administration by100 mg/kg/ of doxycycline. Biochemical tests Estimation of serum urea concentration done, estimation of the effectiveness of some liver enzymes and Tissue preparation technique at last. Results: There was a dose-dependent significant increase in the serum level of hepatocellular leakage enzymes, i.e., AST, ALT, and ALP, with the raised levels at both the 50 mg/kg and 100 mg/kg doses of doxycycline. The Total Serum Bilirubin (T.S.B) levels were also significantly increased in both the treated groups (50 mg/kg and 100 mg/kg) compared to the control group. Also, the serum level of urea and creatinine showed a remarkable increase in all the treated groups (50 mg/kg and 100 mg/kg) when compared with the control group. Conclusions:
This work demonstrates a significant link between doxycycline doses and histological changes in the liver and kidneys of albino rats. In conclusion, doxycycline is an effective medication for treating various conditions, particularly respiratory tract diseases. However, excessive doses or prolonged administration may lead to hepatic and renal toxicities.

Keywords: Doxocycline, kidney functions, liver enzymes, AST, ALT, ALP, .:Total Serum Bilirubin.