DRUG INDUCED HEPATOTOXICITY AFTER INDUCTION PHASE OF CHEMOTHERAPY IN ACUTE LYMPHOBLASTIC LEUKEMIC PATIENTS.

Abdul Sattar, *Aziza Khanam, Sidra Ibad and Ali Iftikhar

ABSTRACT

The present study includes 20 prediagnosed Acute lymphoblastic Leukemic (ALL) and 20 normal control children. The Biochemical parameters (Bilirubin, Alanine amino transferase, Alkaline phosphatase and gamma glutamyl transferase) and complete blood count were investigated in control and leukemic patients. It was found that there was no significant difference between serum level of Bilirubin, Alanine aminotransferase, Alkaline phosphatase in leukemic patients as compared to control normal subjects. The serum Gamma glutamyl transferase of leukemic patients was high as compared to control subjects. There was significant increase in the blood level of Bilirubin, Alanine aminotransferase, Alkaline phosphatase and γ – Glutamyl transferase in patients after chemotherapy (Vincristine, L – asparaginase, Daunomycin, and Methotrexate) as compared to patients before Therapy. There was significant decrease in the number of blast cells and an increase in the level of hemoglobin, RBC, PCV, MCV, and neutrophil in leukemic patients after chemotherapy as compared to patients before chemotherapy. Conclusion: The chemotherapy induced hepatotoxicity, is present in ALL patients.

Keywords: Acute Lymphoblastic Leukemia (ALL), Chemotherapy, Induction phase, Hepatotoxicity, Hematological disorder.